abstract：BACKGROUND:Since the late 1980s, genetic discrimination has remained one of the major concerns associated with genetic research and clinical genetics. Europe has adopted a plethora of laws and policies, both at the regional and national levels, to prevent insurers from having access to genetic information for underwrit...

journal_title：BMC medicine

authors： Joly Y,Ngueng Feze I,Simard J

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Ineffective risk stratification can delay diagnosis of serious disease in patients with hematuria. We applied a systems biology approach to analyze clinical, demographic and biomarker measurements (n = 29) collected from 157 hematuric patients: 80 urothelial cancer (UC) and 77 controls with confounding patho...

journal_title：BMC medicine

authors： Emmert-Streib F,Abogunrin F,de Matos Simoes R,Duggan B,Ruddock MW,Reid CN,Roddy O,White L,O'Kane HF,O'Rourke D,Anderson NH,Nambirajan T,Williamson KE

更新日期：2013-01-17 00:00:00

abstract：BACKGROUND:Mathematical and computational models for infectious diseases are increasingly used to support public-health decisions; however, their reliability is currently under debate. Real-time forecasts of epidemic spread using data-driven models have been hindered by the technical challenges posed by parameter estim...

journal_title：BMC medicine

authors： Tizzoni M,Bajardi P,Poletto C,Ramasco JJ,Balcan D,Gonçalves B,Perra N,Colizza V,Vespignani A

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective forces; thus, we analyze...

journal_title：BMC medicine

authors： Al-Daghri NM,Cagliani R,Forni D,Alokail MS,Pozzoli U,Alkharfy KM,Sabico S,Clerici M,Sironi M

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme ...

journal_title：BMC medicine

authors： Kandadi MR,Yu X,Frankel AE,Ren J

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Interventions to promote positive parenting are often reported to offer good outcomes for children but they can consume substantial resources and they require rigorous appraisal. METHODS:Evaluations of the Triple P parenting program were subjected to systematic review and meta-analysis with analysis of bias...

journal_title：BMC medicine

authors： Wilson P,Rush R,Hussey S,Puckering C,Sim F,Allely CS,Doku P,McConnachie A,Gillberg C

更新日期：2012-11-02 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) can be caused by life threatening illness, such as cancer and coronary events. The study by Forbes et al. made the unexpected finding that military personnel evacuation with medical illness have similar rates of PTSD to those evacuated with combat injuries. It may be that the illn...

journal_title：BMC medicine

authors： McFarlane AC

更新日期：2012-10-24 00:00:00

abstract：BACKGROUND:When an outbreak of a novel pathogen occurs, some of the most pressing questions from a public-health point of view relate to its transmissibility, and the probabilities of different clinical outcomes following infection, to allow an informed response. Estimates of these quantities are often based on househo...

journal_title：BMC medicine

authors： House T,Inglis N,Ross JV,Wilson F,Suleman S,Edeghere O,Smith G,Olowokure B,Keeling MJ

更新日期：2012-10-09 00:00:00

abstract：:The complexity of tissue and the alterations that distinguish normal from cancer remain a challenge for translating results from tumor biological studies into clinical medicine. This has generated an unmet need to exploit the findings from studies based on cell lines and model organisms to develop, validate and clinic...

journal_title：BMC medicine

authors： Kampf C,Bergman J,Oksvold P,Asplund A,Navani S,Wiking M,Lundberg E,Uhlén M,Ponten F

更新日期：2012-09-12 00:00:00

abstract：BACKGROUND:In childhood, attention deficit/hyperactivity disorder (ADHD) is characterized by age-inappropriate levels of inattentiveness/disorganization, hyperactivity/impulsiveness, or a combination thereof. Although the criteria for ADHD are well defined, the long-term consequences in adults and children need to be m...

journal_title：BMC medicine

authors： Shaw M,Hodgkins P,Caci H,Young S,Kahle J,Woods AG,Arnold LE

更新日期：2012-09-04 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it ha...

journal_title：BMC medicine

authors： Zhang SS,Han ZP,Jing YY,Tao SF,Li TJ,Wang H,Wang Y,Li R,Yang Y,Zhao X,Xu XD,Yu ED,Rui YC,Liu HJ,Zhang L,Wei LX

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:The TransEurope FootRace 2009 (TEFR09) was one of the longest transcontinental ultramarathons with an extreme endurance physical load of running nearly 4,500 km in 64 days. The aim of this study was to assess the wide spectrum of adaptive responses in humans regarding the different tissues, organs and functi...

journal_title：BMC medicine

authors： Schütz UH,Schmidt-Trucksäss A,Knechtle B,Machann J,Wiedelbach H,Ehrhardt M,Freund W,Gröninger S,Brunner H,Schulze I,Brambs HJ,Billich C

更新日期：2012-07-19 00:00:00

abstract：BACKGROUND:Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this study was to evaluate whether CPs improve the outcomes and the quality of care provided to patients ...

journal_title：BMC medicine

authors： Panella M,Marchisio S,Brambilla R,Vanhaecht K,Di Stanislao F

更新日期：2012-07-10 00:00:00

abstract：:A series of primarily laboratory-based studies found attention bias modification in socially anxious participants to lead to reduced anxiety. It is argued that the failure to replicate the positive results of attention bias modification in the study of Carlbring et al. may be due to reasons other than the application ...

journal_title：BMC medicine

authors： Emmelkamp PM

更新日期：2012-06-25 00:00:00

abstract：:Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...

journal_title：BMC medicine

authors： Quashie PK,Sloan RD,Wainberg MA

更新日期：2012-04-12 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...

journal_title：BMC medicine

authors： Rudenko IN,Chia R,Cookson MR

更新日期：2012-02-23 00:00:00

abstract：:A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that i...

journal_title：BMC medicine

authors： Sapone A,Bai JC,Ciacci C,Dolinsek J,Green PH,Hadjivassiliou M,Kaukinen K,Rostami K,Sanders DS,Schumann M,Ullrich R,Villalta D,Volta U,Catassi C,Fasano A

更新日期：2012-02-07 00:00:00

abstract：:Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...

journal_title：BMC medicine

authors： Goldwater PN,Bettelheim KA

更新日期：2012-02-02 00:00:00

abstract：:In a climate of economic uncertainty, cost effectiveness analysis is a potentially important tool for making choices about health care interventions. Methods for such analyses are well established, but the results need to be interpreted carefully and are subject to bias. Making decisions based on results of cost-effec...

journal_title：BMC medicine

authors： Hill SR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Iron deficiency without anemia is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of iron treatment after a blood donation. METHODS:One week after donation, we randomly assigned 154 female don...

journal_title：BMC medicine

authors： Waldvogel S,Pedrazzini B,Vaucher P,Bize R,Cornuz J,Tissot JD,Favrat B

更新日期：2012-01-24 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...

journal_title：BMC medicine

authors： Nickel CH,Bingisser R,Morgenthaler NG

更新日期：2012-01-20 00:00:00

abstract：:Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...

journal_title：BMC medicine

authors： Nesse RM,Stein DJ

更新日期：2012-01-13 00:00:00

abstract：:Cocaine is a stimulant that leads to the rapid accumulation of catecholamines and serotonin in the brain due to prevention of their re-uptake into the neuron that released the neurotransmitter. Cocaine dependence is a public health concern and cause of significant morbidity and mortality worldwide. At present, there a...

journal_title：BMC medicine

authors： Shorter D,Kosten TR

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...

journal_title：BMC medicine

authors： Zhang X,Wang M,Gao S,Ren R,Zheng J,Zhang Y

更新日期：2011-10-27 00:00:00

abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...

journal_title：BMC medicine

authors： Weir GA,Cader MZ

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statis...

journal_title：BMC medicine

authors： Lombardo P,Vaucher P,Haftgoli N,Burnand B,Favrat B,Verdon F,Bischoff T,Herzig L

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND:The World Health Organisation estimates that by 2030 there will be approximately 350 million people with type 2 diabetes. Associated with renal complications, heart disease, stroke and peripheral vascular disease, early identification of patients with undiagnosed type 2 diabetes or those at an increased risk...

journal_title：BMC medicine

authors： Collins GS,Mallett S,Omar O,Yu LM

更新日期：2011-09-08 00:00:00

abstract：:Although imatinib is firmly established as an effective therapy for newly diagnosed patients with chronic myeloid leukemia (CML), the field continues to advance on several fronts. In this minireview we cover recent results of second generation tyrosine kinase inhibitors in newly diagnosed patients, investigate the sta...

journal_title：BMC medicine

authors： Eiring AM,Khorashad JS,Morley K,Deininger MW

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Smokers have been shown to have lower mortality after acute coronary syndrome than non-smokers. This has been attributed to the younger age, lower co-morbidity, more aggressive treatment and lower risk profile of the smoker. Some studies, however, have used multivariate analyses to show a residual survival b...

journal_title：BMC medicine

authors： Aune E,Røislien J,Mathisen M,Thelle DS,Otterstad JE

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:In many developing countries, the majority of births are attended by traditional birth attendants, who lack formal training in neonatal resuscitation and other essential care required by the newly born infant. In these countries, the major causes of neonatal mortality are birth asphyxia, infection, and low-b...

journal_title：BMC medicine

authors： Matendo R,Engmann C,Ditekemena J,Gado J,Tshefu A,Kinoshita R,McClure EM,Moore J,Wallace D,Carlo WA,Wright LL,Bose C

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...

journal_title：BMC medicine

authors： Stehlé J,Voirin N,Barrat A,Cattuto C,Colizza V,Isella L,Régis C,Pinton JF,Khanafer N,Van den Broeck W,Vanhems P

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:Studies addressing the effects of aerobic exercise and a prudent diet on lipid and lipoprotein concentrations in adults have reached conflicting conclusions. The purpose of this study was to determine the effects of aerobic exercise combined with a prudent diet on lipid and lipoprotein concentrations in adul...

journal_title：BMC medicine

authors： Kelley GA,Kelley KS,Roberts S,Haskell W

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:Prescription of non-steroidal anti-inflammatory drugs (NSAIDs) should be based on the assessment of both gastrointestinal (GI) and cardiovascular (CV) risk for the individual patient. We aimed to assess the GI/CV risk profile and the pharmacological management of patients with osteoarthritis (OA) in clinical...

journal_title：BMC medicine

authors： Lanas A,Garcia-Tell G,Armada B,Oteo-Alvaro A

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:The rapidly increasing number of activity-induced musculoskeletal injuries among adolescents and young adults is currently a true public health burden. The objective of this study was to investigate whether a neuromuscular training programme with injury prevention counselling is effective in preventing acute...

journal_title：BMC medicine

authors： Parkkari J,Taanila H,Suni J,Mattila VM,Ohrankämmen O,Vuorinen P,Kannus P,Pihlajamäki H

更新日期：2011-04-11 00:00:00

abstract：BACKGROUND:Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degre...

journal_title：BMC medicine

authors： Capo-chichi CD,Cai KQ,Simpkins F,Ganjei-Azar P,Godwin AK,Xu XX

更新日期：2011-03-26 00:00:00

abstract：BACKGROUND:Chronic fatigue syndrome (CFS) is a complex multifactorial disorder. This paper reports the prevalence of chronic fatigue (CF) and CFS in an ethnically diverse population sample and tests whether prevalence varies by social adversity, social support, physical inactivity, anxiety and depression. METHODS:Anal...

journal_title：BMC medicine

authors： Bhui KS,Dinos S,Ashby D,Nazroo J,Wessely S,White PD

更新日期：2011-03-21 00:00:00

abstract：BACKGROUND:Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. METHODS:To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed ...

journal_title：BMC medicine

authors： Chang CY,Chang HW,Chen CM,Lin CY,Chen CP,Lai CH,Lin WY,Liu HP,Sheu JJ,Tsai FJ

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed t...

journal_title：BMC medicine

authors： Bosl W,Tierney A,Tager-Flusberg H,Nelson C

更新日期：2011-02-22 00:00:00

abstract：:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic A...

journal_title：BMC medicine

authors： Munshi R,Hsu C,Himmelfarb J

更新日期：2011-02-02 00:00:00

abstract：BACKGROUND:Persistent disabilities are key manifestations of Chikungunya virus (CHIKV) infection, especially incapacitating polyarthralgia and fatigue. So far, little is known about their impact on health status. The present study aimed at describing the burden of CHIKV prolonged or late-onset symptoms on the self-perc...

journal_title：BMC medicine

authors： Gérardin P,Fianu A,Malvy D,Mussard C,Boussaïd K,Rollot O,Michault A,Gaüzere BA,Bréart G,Favier F

更新日期：2011-01-14 00:00:00